Healthcare: highly cited animal studies
Hackam & Redelmeier. Translation of research evidence from animals to humans. [research letter]. JAMA 2006; 296(14): 1731-2.
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INTRODUCTION
Most medical therapies in use today were initially developed and tested in animals, yet animal experiments often fail to replicate when tested in rigorous human trials. We conducted a systematic review to determine how often highly cited animal studies translate into successful human research.