Hackam & Redelmeier. Translation of research evidence from animals to humans. [research letter]. JAMA 2006; 296(14): 1731-2. Download
(115 kb). INTRODUCTION
Most medical therapies in use today were initially developed and tested in animals, yet animal experiments often fail to replicate when tested in rigorous human trials. We conducted a systematic review to determine how often highly cited animal studies translate into successful human research.